Bipolar disorder

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On September 1st, 1773, Boswell, Johnson and their servants set out on horseback for the crossing to the island of Skye.

johnson-by-opieIt grew dusky; and we had a very tedious ride for what was called five miles; but I am sure would measure ten. We had no conversation. I was riding forward to the inn at Glenelg on the shore opposite to Sky, that I might take proper measures, before Dr Johnson, who was now advancing in dreary silence, Hay leading his horse, should arrive. Vass also walked by the side of his horse, and Joseph followed behind: as therefore he was thus attended, and seemed to be in deep meditation, I thought there could be no harm in leaving him for a little while. He called me back with a tremendous shout, and was really in a passion with me for leaving him. I told him my intentions, but he was not satisfied, and said, ‘Do you know, I should as soon have thought of picking a pocket, as doing so.’

BOSWELL. ‘I am diverted with you, sir.’

JOHNSON. ‘Sir, I could never be diverted with incivility. Doing such a thing, makes one lose confidence in him who has done it, as one cannot tell what he may do next.’

His extraordinary warmth confounded me so much, that I justified myself but lamely to him; yet my intentions were not improper. I wished to get on, to see how we were to be lodged, and how we were to get a boat; all which I thought I could best settle myself ? I however continued to ride by him, finding he wished I should do so.

Next morning, the quarrel is made up. Johnson owns that he spoke in passion, Boswell that he took it too hard, and they set out in a boat for Skye. Read the rest of this entry »

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People with clinical depression worry about transmitting the genes to their children, and with good reason, because it is strongly heritable. But as this cheery article in The Times points out, genes and environment interact.

The serotonin transporter gene, 5HTT, also has two alleles, and is known to be involved in mood. Moffitt and Caspi found that people with one allele were 2.5 times more likely to develop clinical depression than those with the other – but, again, only under particular circumstances. The risk applies only to people who also experience stressful life events such as unemployment, divorce or bereavement. When their environments are happy, their genotypes made no difference.

The ghost of Samuel Johnson whispers:

Yet hope not life from pain or danger free,
Or think the doom of man reversed for thee

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I’m reading through the suitcase of memories – well, not ‘through’, I stop and stare into space and rootle around for more of something. There are some letters from a girl with whom I had a brief encounter. My whole pre-suitcase memory of that was: I Did her Wrong, she wrote angrily to me, I didn’t reply, I was a Rat with Women.

The reality conveyed by the letters is completely different. Seems I did write, and here’s part of the response:

Believe me, I’ve no regrets, only a great deal of happiness to look back on.

There are more letters. Seems also that I was exploring the possibility of leaving for her city – permanently? – and although she was now involved with someone else, she was busy organising a job and somewhere to stay. Kindness and care, when all I had remembered was rage and betrayal. Read the rest of this entry »

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